Human Corneal Endothelial Cells Employ Phosphorylation of p27Kip1 at Both Ser10 and Thr187 Sites for FGF-2-Mediated Cell Proliferation via PI 3-Kinase

摘要

FGF-2 stimulates proliferation of human CECs through PI 3-kinase and its downstream target ERK1/2 pathways. This signal transduction downregulates p27 through its phosphorylation at both Ser10 and Thr187 sites mediated by KIS and Cdc25A, respectively.